Page 230 - 知識饗宴
知
·
識
·
饗
·
宴
KNOWLEDGE
FEAST SERIES
230
Antimalarial
1
Anticancer
2
Anti-AIDS
3
˂್
ي
ഐ࿴
ࡌ
ུ
ي
Ъ͜ዚଣ
Artemisinin
Artemether,
Arteether
Damages parasite
proteins
Taxol
Taxotere Promotes microtubule
assembly
Vincristine,
Vinblastine
Vindesine,
Vinorelbine
Inhibits microtubule
assembly
Podophyllotoxin Etoposide
Teniposide
Inhibits DNA topo II
Irinotecan,
Hycamptin
Inhibits DNA topo I
Betulinic acid
Camptothecin
Bevirimat
(
MPC-4326)
Inhibits HIV maturation
(
Phase IIb clinical trials)
೯
ତ
ۍ
݊ϜұਗɛٙfෂႭʕd؇ဏ͋ϋ€ʮʩ
171
ä
185
˜ᔼ໋™ੵ΀౻ਂ
ڗ
Ӎ˄ςࣛdϞɓϋෆఫɽ
ݴ
Бd˼ٙૄɛϥəɚϵεɛd˼Ϊ
މ
ᔼஔ
৷੬ڢ
׼dШ
ۍ
ೌ
طج
λϤषdவԴ˼ᙂ੻
ܘ
Ϩᕙf຅˼ైైʔᆀ
ൺՑཞኣӀ୿̘౳ːࣛd߉್ගจ̮ή೯ତཞኣٙӀ͏
ӚϞɓ
ࡈ
ɛ੻ෆఫd˼ఱਪ˼
ࡁ
Ⴍj˜Ы
ࡁ
ӊɓ˂ٙ͛
ݺ
ৎ֢ேΦəఀəʡჿk™˼
ࡁ
Ⴍj˜Ң
ࡁ
ӊ˂ே͜
ڡ
ႃ
ظ
঩ఀ™f˼Ϋ̘ν
ޏج
Ⴁd
؈
್
ڗ
Ӎԟ
ࡈ
ή੭ٙෆ
ఫဳशɓɨɿఱ஗
ط
λəf᙮׵ീ߅ʘ
ڡ
ႃࡡಔ
ي
Ϟ஢
εʔΝٙۜ၇dШ̥Ϟර
ڀ
ٙ
ڡ
ႃdර
ڀ
ႃ€
Artemisia
annua
dўϞ
ڡ
ႃ९€
Artemisinin
d̙ԈᑺӺ༸ήᖹ
圖三：現今臨床上使用或臨床試驗中之抗瘧，抗癌，與抗愛滋病新藥研發實例
（
1
www.laskerfoundation.org/awards/2011_c_description.htm;
2
Lee KH,
J. Nat. Prod
., 2010, 73, 500;
3
Qian K et al,
Nat. Prod. Chem. for Drug
Discovery
,
RSC, 2009, 13, 374
）