中草藥與新藥研發
231
˂್
ي
Natural
ഐ
ࡌ
ུ
ي
Modified
Ƕ
Taxol
(
Diterpene)
Ƕ
Vincristine
R = CHO
Vinblastine
R = Me
(
Alkaloids)
Ƕ
Vindesine
Ƕ
Vinorelbine
O
O
O
AcO
AcO O
O
O
O
Ph
Ph
Ph
OH
OH
HO H
NH
O
O
O
HO
AcO O
O
O
O
Me
3
CO
Ph
Ph
OH
OH
HO H
NH
COOCH
3
H
3
CO
2
C
H
3
CO
OAc
H
H
N
N
R
N
N
H
OH
OH
Ƕ
Taxotere
CONH
2
H
3
CO
2
C
H
3
CO
OH
H
H
N
N
R
N
N
H
OH
OH
COOCH
3
H
3
CO
2
C
OAc
H
3
CO
H
H
N
N
R
N
N
H
OH
OH
ҿʘࠠ
ࠅ
fʕɽ೯
ڡ
ႃ९d
WHO
ו
Ⴉ݊Ό˰
ޢ
ط
ᐕဳश௰λٙᖹd್Ͼਬɓ፲ኴٙ݊ɽٙኪ٫
ࡁ
˼
ࡁ
ԟࣛ
ࡉ
ӚϞ͡ሗਖ਼лdഐ
؈
ఱ
ߕ
ʘ
Buchs
ၾ
Brossi
1991
ϋ༶͜ᔼᖹʷኪٙ˙
ج
dҪ̴ٙଡ଼ϓᔊήҷႡ
ϓ
2
ࡈ
Ϟਖ਼л
ڭ
ᚐϾ˲ࣖ
؈
ˢ
ڡ
ႃ९һ੶ٙ
Artemether
ၾ
Arteether
ྡɧʿྡʬfл͜ᔼᖹʷኪٙ˙
ج
̙˸Ⴠ
ή௴ிอᖹϤ̙Ԉf
࠽
ɓٙ݊
ڡ
ႃ९ٙ೯๕
ɽ˖ࠧࣛಂʘණ௴Ъd̴݊ɽ࣬ኽଣʕᔼᖹ
ՊᘬϾක೯̈Ըٙ˰
ޢ
ॴอᖹd࿁ɛᗳ
ط
ᐕဳश্ٙᘠ
ɽdΪϤ
ז
дਿ
ږ
ึ
Lasker Foundation
ί
2011
ϋ
೯ഗ௰
೯ڋ
ତ
ڡ
ႃ९ʘਜ਼ᤪᤪબɓ
ࡈ
ɽᆤd
ז
圖四：現今臨床上使用抗癌新藥研發實例（
Lee KH,
J. Nat. Prod
., 2010, 73,
500
）
