中草藥與新藥研發
229
naturalis
ஷཀᔼᖹʷኪʘ೯ഐ
؈
d
ۍ
೯ତўϞҤͣ
АषʘϞࣖϓʱ
Indirubin
᎐͗
ߎ
dආБഐ
ࡌ
ུ
ܝ
d
ʊ೯ତһϞࣖʘҤᐖ
ࠃ
͛
ي
ሯ͜˸
ط
ᐕ࿔৶ͣАष
Chronic myelocytic leukemia
ྡɚfϤԬʷΥ
ي
ʊ
ڋ
Ӊᗇྼ݊
Kinase
ʘҵႡኒd࿁
CD K1/cyclin B
Ϟ
5
࠴
੶ʘत֛ҵՓЪ͜f
3.
ڡ
ႃ
Ύᑘɓ
ࡈ
Էɿఱ݊
ڡ
ႃd
ڡ
ႃί͉ণ͵Τ
ণႃf
ڡ
ႃίГʩ
340
ϋ؇ࣜ
ݳ
ٙԀ
ܢ௪ܝ
˙ʕϞᔊ
ٙা༱j
ط
ఫᆠመဳd
ڡ
ႃ˸ɓ˸˥ɚʺဌdഏ
՟
͒းdఱ݊Ⴍ༾Ϟෆఫဳशࣛd̥
ڡ՟ࠅ
ႃd͜
˓࣍ɓҪd̋ɪɚʺٙ˥dҪ̴ऍ
ظ
d್
ܝ
Ҫவ
ࡈ
͒ఀ
ɨ̘ఱ̙˸ਗ̴਼
ط
λədவ
ࡈ
া༱ᒱ್ᔊdШ̴݊ٙ
R
R
3
R
2
R
1
R
1
= H; R
2
= Br; R
3
= O
R
1
= H; R
2
= Br; R
3
= NOH
O
O
CH
3
N
H
N
H
NH
O
NH
NHCH
3
Ƕ
Ephedrine (l-form)
௦
ර९
R = OH
Ƕ
Psedoephedrine (d-form)
৽௦ර९
R = OH
Sudafed
Ƕ
Indirubin
᎐͗
ߎ
᎐͗
ߎ
ʘอ
ࠃ
͛
ي
圖二：麻黃素與靛玉紅（
Cragg GM & Newman DJ,
Comprehensive Natural
Products II: Chemistry & Biology
,
Elsevier: Oxford, 2010, 3, 135, and
literature cited therein
）
