亂中有序
215
ϋdϞɓᇐ
Science
ሞ˖
2001
Jul 6; 293(5527):115-120
d
Ъ٫͟ɓԬ͛ʷྼ᜕d೯ତ
APP
ٙ˪
ݬ
ึၾ
Fe65
e
Tip60
ഐΥdவᜑ̴ͪ
ࡁ
̌ঐϞᗫfШҢ
ࡁ
ίਿΪ
ڌ
ତ༟ࣘɪ
ԈʔՑᗫd
ה
˸ఱҪ
APP
X
eҪ
Tip60
Y
dϾҪ౺˪
ΌਿΪɽ฿ਗ਼
ڐ
ɓຬ
ࡈ
Z
dீཀ
Liquid association
ʱؓ
ܝ
dίୋɚනЗఱҬՑ
PSEN1
d̴݊ƻ
-
ʱ
ؤ
酶
gamma-
secretase
i̤̮d Ң
ࡁ
Ҫ
APP
X
eҪ
Fe65
Y
d
LA
Ҭ
Ցٙ݊
BACE2
d̴݊९
beta-site APP-cleaving enzyme
fவ
Շ
ࡈ
९ࡡԸఱ݊
ࠋ
பʲ௲
APP
ٙԟՇ၇९fᔊఊԸႭd
ீཀ
Liquid association
dఱ̙˸
ܘ
̷Ѷٙ͟౺˪ਗ਼
ڐ
ɓຬ
ࡈ
ਿΪ༁᎘dҬ̈Ո͛
ي
จ່ٙਿΪdவ݊ɓছ͛
ي
ྼ᜕
ה
ᗭ˸༺ՑٙͦᅺdίϤ
ۍ
̙ீཀ
LA
Ⴠᕦٙҁϓf
LA
Ꮠ͜Էɧjε೯ʷस
Multiple Sclerosis,
MS
Г˙ɛε೯ʷस
MS
fɓছႩ
މ
MS
݊І
е
ޥ
शषd͟е
ޥ
ӻ୕ҸᏘʕᅹग़dҪ̮ࠦഒᇝٙ
᎓
Myelin Sheath
ॎᕸદədϾ᎓݊ਖ਼ப
ڭ
ᚐग़ʩ
neurone
ٙই
ٴ
ᄴd͟ʕᅹग़ӻ୕ቊՑॎᕸd˸Ї
ܘ
εЗʷ
א
ఄ̰əࡡ͉ٙ̌ঐfҢ
ࡁ
݊˸ਿΪ
ڌ
ତٙ
༟ࣘdீཀ
Liquid association
̘ʱؓdՉʕɛ໘᎓ஐ
ͣ
Myelin basic protein
d
MBP
d̴ίग़
ߤ
̮ᄴ༁᎘
ڌ
ତ
੬ڢ
εd
ה
˸Ңਗ਼
MBP
ਿΪЪƄfၾҢΥЪԸІ
ځ
ᚆٙӺྠඟί˼
ࡁ
ཀ̘፲ෂӺҬՑɓ
ࡈ
MS
ٙ
candidate
gene
d
PRKCA
protein kinase C alpha
d݊Ҫ˼Ъ
