知
·
識
·
饗
·
宴
KNOWLEDGE
FEAST SERIES
214
ϓ
Y
dҪӊɓ
ࡈ
ਿΪᐼϞ
6
ɷ
ࡈ
ਿΪ̸̛ϓ
Z
dʱ
й̘
ࠇ
ၑ
LA
࠽
d್
ܝ
Ա
LA
࠽
રΐਿΪd̘͍
௰࠽ࠋא࠽
੶ٙਿΪdҢ
೯ࡁ
ତί
࠽ࠋ
ٙɓ၌dરΤୋ
8
ٙ݊ᶶਿ͠。
ᐟაΥϓ
酶
CPA2
ٙਿΪfΎ˺̘҇९ృᐑྡ
ɚd ࡡԸ
ARG2
ᄣ̋ி̈ᶶა
ܝ
d
ࠅ
ᜊϓ͘ᶶაٙˀ
Ꮠʕ݊ც
ࠅ
ऄਿ͠
酰
ᐟა
carbamyl phosphate
dϾ
CPA2
͍λ̙л͜ኅ。ᶶა
glutamine
ி̈ऄਿ͠
酰
ᐟაԸৣ
ΥfΫՑྡɧd
CPA2
ڌ
ତඎεࣛd˾
ڌ
ߤ
ஈც
ࠅ
ၚ
ᶶაًٙ࿒dҢ
ࡁ
Ց
ARG2
༧
CAR2
ఱλяତ
ࠋ
ᗫf
ˀٙd
CPA2
ڌ
ତඎˇࣛd˾
ڌ
ߤ
ʔΎც
ࠅ
ၚᶶაd
Ң
ࡁ
ఱՑ
ARG2
༧
CAR2
яତ͍ᗫdλᜫεቱٙᶶა
ʿࣛ˾ᑽf
ίவɓ
ࡈ
ʃ
ߤ
༁πίνϤฆѶٙᗫ
ڷ
d
6
ɷ
ࡈ
ਿΪʕ
̥ቦഹਿΪٙ
ڌ
ତඎd
ڌ
ࠦɪЧ૩ೌᗫdШν
؈
ঐഛ
̋л͜୕
ࠇ
˙
ج
d͟ତϞʊ̘ٝપԟԬ͊ٝٙd̙݊˸
Ҭ̈ɓԬΥଣٙ͛
ي
จ່f
LA
Ꮠ͜Էɚj
ڛ
ধऎᎰस
Alzheimer's disease,
AD
ڛ
ধऎᎰसуҢ
ࡁ
ᆞٝٙϼϋᖝьઃ٫໘㛪ٙ
෯d˴
ࠅ
͟ɔۨÑዠ४ᅵஐͣ
beta amyloid
ה
ଡ଼ϓf
beta amyloid
݊ɔۨÑዠ४ᅵஐͣ
ۃ
ᚨஐͣ
Amyloid-beta
precursor protein, APP
Շϣ९Ъ͜ʲ௲̈Ըٙʃஐͣ
ሯf
APP
ίɓছ͛ଣɪٙЪ͜dՉྼ݊ʔ˄ูfί
2001