Page 235 - 知識饗宴

中草藥與新藥研發
235
圖六：現今臨床上使用或臨床試驗中之抗瘧與抗愛滋病新藥研發實例（Buchs P
& Brossi A, US Patent 5,011,951, granted on 4/30/1991）
˂್ي Natural ഐ࿴ ࡌུي Modified
ǶArtemether R = CH3
Arteether 1 R = CH2CH3
Ƕ Betulinic Acid
(Triterpene) Ƕ Bevirimat
ǶArtemisinin
(Sesquiterpene)
H
H
H
H
H
H
O
O H
H HO
COOH
HOOC
COOH
O
O
H H
O
O
O O
O
H H
O
OR
O
ʗਞ݊ Salvia miltiorrhiza ٙ࣬୻f֐༱׵ग़༵͉ণ
຾dΐމɪۜfʗਞٙЪܼ̍͜ᓒੵڿ ًਗএdʕᔼ޴ڦ
ʗਞ̙ཫԣА૰ᝨጐձːЄ૚෦fʗਞʘϞࣖϓʱϞ˥
๓׌ձই๓׌Շɽᗳf˥๓׌ϞSalvianolic Acid Bdই๓
׌ϞTanshinone IձTanshinone IIA ഃϓʱfTanshinone IIA-
Sodium Sulfonate˥๓׌੶d͜׵ طᐕڿːषeːഏ೨ʿܢ
׌ːЄ૚෦fՈϞᓒੵڿ ًਗএeڮආଡ଼ᔌ ࡌూe ڭᚐߎ
୚ߤ ᇫʿڜ ထඑஷ༸Ъ͜fʗਞই๓׌ʷኪϓʱٙ޼Ӻආ
ɓӉաՑ޼Ӻ٫ٙࠠൖdʔᓙϞอٙʷΥيజኬfҢ ࡁɰ
೯ତə Neo-tanshinlactonedϤ يഐ࿴อ጑d࿁׵Ԫ໗ᐖϞ