中草藥與新藥研發
233
˂್
ي
Natural
ഐ
ࡌ
ུ
ي
Modified
Ƕ
Podophyllotoxin
(
Lignan)
Ƕ
Hycamptin
Ƕ
Irinotecan
Ƕ
Camptothecin
(
Alkaloid)
Ƕ
Etoposide
R = CH
3
Teniposide
R =
HO
O
O
O
O
H
3
CO
OCH
3
OCH
3
O O O
O
OH
O
O
O
O
H
3
CO
OCH
3
OH
HO
R
N
N O
O
O
HO
N
N N
O
CO
N O
O
O
HO
N
S
N O
O
O
HO
HCI
HCI
HO
NMe
3
圖五：現今臨床上使用抗癌新藥研發實例
–2
（
Lee KH,
J. Nat. Prod
., 2010, 73,
500
）
ي
ʿՉΥϓ
ࠃ
͛
אي
ᗳЧ
ي
dՉʕϞ၇ʊආɝᑗґ༊
᜕fҢ
ڋ௰ࡁ
˸ग़༵͉ণٙɨۜণᖹ
މ
ܸኬࡡ
ۆ
dක೯Ҥᐖᖹ
ي
fνГᔛ৺Ј
Podophyllum emodi
༱
ग़༵͉ণʘɨۜdՉ
ݺ
ي
ሯ৺Ј
९ݭ
podophyllotoxin
̙৺ЈʕʱᕎϾd
1980
ϋ
ڋ
ಂd
ɻ
Sandoz
ʮ̡ਗ਼
Podophyllotoxin
ʷኪ
ࡌ
ུՑՉ
ࠃ
͛
ي
Ա
ৄ
غ
苷
Etoposide
dʊ͜
ط
ᐕʃ
٬ߤ
ᐖe❆ɬᐖe
ˋᆯ˸ʿͣАषf್Ͼd̴ٙਓЪ͜
މ
j͛
ي
̙л͜ଟ
ЭeԨϞପ͛৶ҵՓၾᖹ
ߗي
աʘॹᓃfΪϤdҢ
ࡁ
ک
˸ᔼᖹʷኪٙ˙
ج
ண
ࠇ
e
ࡌ
ҷՉʷኪഐdΥϓəᅰϵ
၇
ʘอ
Epipodophyllotoxin
ᗳЧ
ي
dԨீཀၾቍ͑ᄁ৫ɻʘ
ΥЪd˸
DNA
ן
ᅝମ
II
DNA Topoisomerase II
މ
͛
ي
