Page 104 - 知識饗宴

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Иd ה˸࿴ிே݊еޥ ୚הߤ ᆞᗆٙᅵɿdˢ༰ʔึϞཀ
ઽˀᏐfˀʘ HLA-B*1502ၾCBZҖϓٙ࿴ிܘᖢ֛dʔᓙ
ٙՐዧеޥЪ͜d௰ܝኬߧSJSᘌࠠٙसًf
᜕ᗇࡈɛʷᔼኪ̙ٙБ׌
Ϟəϓ̌ٙ޴ᗫ޼Ӻၾዚᔷ޼ӺdɨɓӉఱ᜕݊ᗇ݊
щ˜͜ CBZ ۃٙ HLA-B*1502ਿΪጜᏨdίቇ຅ٙᑗґᐑ
ྤʘɨdఱঐཫԣ͜ᖹʘ ܝٙ SJS™k༺ࠅՑவͦᅺd࠯
΋ ࠅϽᅇජ׌ཫ಻༧࠽ ௕׌ཫ಻࠽ €ྡɖd৿ண݊ɓࡈ
ɛ HLAB*1502ජ׌dΦ CBZʘ ܝఱึ SJS ཀઽٙˢଟఱ݊
HLA-B*1502
CBZ-SJS (+) (-)
圖七
[A/(A+C)/B/(B+D)],HLA-B*1502ජ׌ٙɛ؂CBZ ܝ੻SJSٙዚଟ݊
HLAB*1502௕׌ٙɛٙ1357࠴
Sendઽชܓd؂͜CBZ੻ՑSJSϞεˇ݊੭ϞHLA-B*1502
Spcdतମܓd؂͜CBZʔ੻SJS Ϟεˇʔ੭ϞHLA-B*1502
PPVdජ׌ཫ಻࠽d੭ϞHLA-B*1502؂CBZ ܝϞεˇ̙ঐึ੻SJS
NPVd௕׌ཫ಻࠽dӚϞHLA-B*1502؂CBZܝϞεˇ̙ঐʔ੻SJS
޴࿁Κᎈ׌i1357; CBZ-SJS/TEN೯͛ଟd0.25Ĉ
Yes A B Sen=A/(A+B),98.3%
No C D Spc=D/(C+D),95.8%
PPV=A/(A+C) NPV=D/(B+D)
5.6% 99.9%